Molecular System Bioenergetics

In this first integrated view, practically each of the world's leading experts has contributed to this one and only authoritative resource on the topic. Bringing systems biology to cellular energetics, they address in detail such novel concepts as metabolite channeling and medical aspects of metabolic syndrome and cancer.

Autorentext
Valdur Saks is Professor of Bioenergetics and Biochemistry at the University of Grenoble, France, and Head of the Laboratory of Bioenergetics at the National Institute of Chemical and Biological Physics in Tallinn, Estonia. A graduate of Moscow University, he was the long-time head of the Laboratory of Cardiac Bioenergetics in Moscow, Russia, before taking up his present positions. Professor Saks has authored over 220 scientific publications and has received numerous scientific awards, including the USSR State Prize in Science and the Internatinoal "Research and Development" Award sponsored by the U.N. and UNICEF. He is a member of the International Society for Heart Research and of the American Physiological and Biophysical Societies.

Klappentext
Every organism must consume energy to survive. The food we eat is ultimately converted into chemical fuel for our cells, and the availability (or non-availability) of these fuels determines whether cells may grow and divide or starve and die. Not surprisingly, the energy metabolism is a key factor in sustaining or blocking the unlimited growth of cancer cells. In this first integrated view, practically each of the world's leading experts has contributed to this one and only authoritative resource on the topic. Following an introduction, they go on to discuss the basic principles, organization and dynamics of cellular energetics, as well as energy transfer networks, metabolic feedback regulation and modeling, finishing off with a section on applied molecular system bioenergetics. With its combination of systems biology and cellular energetics, this is an invaluable reference for biochemists, biophysicists, cell and molecular biologists, as well as bioengineers.

Zusammenfassung
In this first integrated view, practically each of the world's leading experts has contributed to this one and only authoritative resource on the topic. Bringing systems biology to cellular energetics, they address in detail such novel concepts as metabolite channeling and medical aspects of metabolic syndrome and cancer.

Inhalt
Introduction MOLECULAR SYSTEM BIOENERGETICS: BASIC PRINCIPLES, ORGANISATION AND DYNAMICS OF CELLULAR ENERGETICS Cellular Energy Metabolism and Integrated Oxidative Phosphorylation Organization and Regulation of Mitochondrial Oxidative Phosphorylation Integrated and Organized Cellular Energetic Systems: Theories of Cell Energetics, Compartmentation and Metabolic Channeling On the Network Properties of Mitochondria Structural Organization and Dynamics of Mitochondria in the Cells In Vivo ENERGY TRANSFER NETWORKS, METABOLIC FEEDBACK REGULATION AND MODELING OF CELLULAR ENERGETICS Mitochondrial VDAC and its Complexes Phospho-Creatine Circuit: Integration of Adenylate Kinase, Glycolytic and Glycogenolytic Circuits in Cellular Energetics Signaling by AMP-Activated Protein Kinase Developmental and Functional Consequences of Disturbed Energetic Communication in Brain of Creatine Kinase Deficient Mice System Analysis of Cardiac Energetics - Excitation-Contraction Coupling Principles of Mathematical Modeling and In Silico Studies of Integrated Systems of Cellular Energetics Modeling Energetics of Ion Transport, Membrane Sensing and System Biology of the Heart APPLIED MOLECULAR SYSTEM BIOENERGETICS Mitochondrial Adaptation to Exercise and Training - A Physiological Approach Mitochondrial Medicine: The Central Role of Cellular Energetic Depression and Mitochondria in Cell Pathophysiology Tumour Cell Energetic Metabolome AMPK and the Metabolic Syndrome A Systems Biology Perspective of Obesity and Type 2 Diabetes

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