Introduction to Macromolecular Binding Equilibria

This compact, graduate-level text focuses on a key area of biophysical chemistry. Introduction to Macromolecular Binding Equilibria first describes the features of binding sites for small molecules and then presents a discussion of the formulation of binding isotherms for simple mathematical models. The book addresses special problems in describing isotherms for linear polymers and examines the complications of binding cooperativity and thermodynamic linkage interactions among multiple ligands. It highlights important aspects of experimental designs, key aspects of ligand binding to planar arrays of sites, and methods for model-free analysis data used to reveal the binding isotherm.

Zusammenfassung
Macromolecules in the body form noncovalent associations, such as DNA-protein or protein-protein complexes, that control and regulate numerous cellular functions. Understanding how changes in the concentration and conformation of these macromolecules can trigger physiological responses is essential for researchers developing drug therapies to treat

Inhalt
Binding sites. Binding isotherms. Binding linkage, binding competition, and multiple ligand species. Cooperativity. Binding to lattices of sites. Choosing a method and analyzing the data. Appendix: The sequence-generating function method. Index

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