Targeted Radionuclide Tumor Therapy

The ambition of the editors of this volume is to enable deeper insights into the process of improving targeted radionuclide therapy. They believe that the time has now come when targeted therapy can soon be added to standard oncology treatment regimens.


The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. While considerable advances have been reported, there is still a signi- cant amount of work left to accomplish before our ambitions can be achieved. It now seems timely to review the accomplishments achieved to date and to clarify the challenges that remain. The choice of radionuclide, the conjugation p- cedure employed, and the selection of suitable targets were early issues that were faced by our field that still persist, however we can now tackle these obstacles with significantly better insight. The expanding array of new targeting molecules (recombinant antibodies, peptides and agents based upon alternate scaffolds) may increase the therapeutic efficacy or even modify the radiation sensitivity of the targeted tumor cell. The title of this book Targeted Radionuclide Tumour Therapy Biological Aspects was selected to reinforce the concept that a major focus of this volume was devoted to understanding the biological effects of targeting and radiation. These important issues have not previously been the primary focus in this context. Furthermore, our rapidly expanding knowledge of different types of cell death and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future.

Focus on biological effects of targeted radionuclide therapy Comprehensive presentation of different mechanisms of tumor cell death Up-to-date presentation of new targeting agents Summaries of present state of clinical applications of targeted therapy Introduction of the new concept; Autosensitization during radionuclide therapy

Inhalt
to Radionuclide Therapy.- Therapeutically Used Targeted Antigens in Radioimmunotherapy.- EGFR-Family Expression and Implications for Targeted Radionuclide Therapy.- Targeting Tumours with Radiolabeled Antibodies.- Antibody Fragments Produced by Recombinant and Proteolytic Methods.- Novel Alternative Scaffolds and Their Potential Use for Tumor Targeted Radionuclide Therapy.- Peptides for Radionuclide Therapy.- Choice of Radionuclides and Radiolabelling Techniques.- High-LET-Emitting Radionuclides for Cancer Therapy.- Targeted High-LET Therapy of Bone Metastases.- The Auger Effect in Molecular Targeting Therapy.- Radiation Induced Cell Deaths.- Radiation Induced DNA-Damage/Repair and Associated Signaling Pathways.- Radiation Induced DNA Damage Checkpoints.- Cancer Stem Cells and Radiation.- Effects of Low Dose-Rate Radiation on Cellular Survival.- Bystander Effects and Radionuclide Therapy.- Enhancing the Efficiency of Targeted Radionuclide Therapy.- Low Dose Hyper-Radiosensitivity: A Historical Perspective.- Clinical Radionuclide Therapy.- Developmental Trends in Targeted Radionuclide Therapy: Biological Aspects.

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