Fundamentals of Contemporary Mass Spectrometry

Mass spectrometry has played a pivotal role in a variety of scientific disciplines. This title provides an overview of modern mass spectrometry instrumentation, techniques, and applications, including the developments. It includes hints and solutions to the exercises.

Autorentext
Chhabil Dass, PhD, is an Associate Professor in the Department of Chemistry at The University of Memphis. He is the author of Principles and Practice of Biological Mass Spectrometry (Wiley-Interscience).

Klappentext
Modern mass spectrometry - the instrumentation and applications in diverse fields Mass spectrometry has played a pivotal role in a variety of scientific disciplines. Today it is an integral part of proteomics and drug discovery process. Fundamentals of Contemporary Mass Spectrometry gives readers a concise and authoritative overview of modern mass spectrometry instrumentation, techniques, and applications, including the latest developments. After an introduction to the history of mass spectrometry and the basic underlying concepts, it covers: * Instrumentation, including modes of ionization, condensed phase ionization techniques, mass analysis and ion detection, tandem mass spectrometry, and hyphenated separation techniques * Organic and inorganic mass spectrometry * Biological mass spectrometry, including the analysis of proteins and peptides, oligosaccharides, lipids, oligonucleotides, and other biological materials * Applications to quantitative analysis Based on proven teaching principles, each chapter is complete with a concise overview, highlighted key points, practice exercises, and references to additional resources. Hints and solutions to the exercises are provided in an appendix. To facilitate learning and improve problem-solving skills, several worked-out examples are included. This is a great textbook for graduate students in chemistry, and a robust, practical resource for researchers and scientists, professors, laboratory managers, technicians, and others. It gives scientists in diverse disciplines a practical foundation in modern mass spectrometry.

Zusammenfassung
A concise and authoritative overview of mass spectrometry instrumentation, techniques, and applications in a very readable, user-friendly format filled with chapter summaries, exercises and answers, and references to useful outside resources. * Includes numerous exercises in every chapter, with the answers at the back of the book.

Inhalt
PART 1: INSTRUMENTATION. 1. BASICS OF MASS SPECTROMETRY. 2. MODES OF IONIZATION. 3. MASS ANALYSIS AND ION DETECTION. 4. TANDEM MASS SPECTROMETRY. 5. HYPHENATED SEPARATION TECHNIQUES. PART 2: ORGANIC AND INORGAANIC MASS SPECTROMETRY . 6. ORGANIC MASS SPECTROMETRY. 7. INORGANIC MASS SPECTROMETRY. PART 3: BIOLOGICAL MASS SPECTROMETRY. 8. PROTEINS AND PEPTIDES: STRUCTURE DETERMINATION. 9. Proteins and Peptides: Post-Translational Modifications Disulfide Bonds in Proteins. 10. Proteins and Peptides: Higher-Order Structures. 11. Characterization of Oligosaccharides. 12. Characterization of Lipids. 13. Structure Determination of Oligonucleotides. 14. Quantitative Analysis. 15. Misclaneous Topics. Appendix A: Abbreviations. Appendix B: Physical Constants, Units, and Conversion Factors . Appendix C: Isotopes of Naturally Occurring Elements and their Abundances. Appendix D: Reference Ions and Their Exact Masses. Appendix E: Internet Resources. Appendix F. Answers and Hints to Exercises. Index.

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