Drug Delivery Strategies

Informationen zum Autor Dennis Douroumis University of Greenwich, UK Alfred Fahr Friedrich-Schiller University of Jena, Germany Klappentext Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development oftechniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies.Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, polymeric drug encapsulation delivery systems, self-microemulsifying drug delivery systems, nanocrystals, hydrosol colloidal dispersions, microemulsions, solid dispersions, cosolvent use, dendrimers, polymer- drug conjugates, polymeric micelles, and mesoporous silica nanoparticles. For each approach the book discusses the main instrumentation, operation principles and theoretical background, with a focus on criticalformulation features and clinical studies. Finally, the book includes some recent and novel applications, scale-up considerations and regulatory issues.Drug Delivery Strategies for Poorly Water-Soluble Drugs is an essential multidisciplinary guide to this important area of drug formulation for researchers in industry and academia working in drugdelivery, polymers and biomaterials. Zusammenfassung Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. This work addresses the latest techniques and materials to overcome these hurdles, providing a thorough review of current formulation strategies for a wide range of hydrophobic drugs. With a focus on critical formulation features and clinical studies, the book covers instrumentation, operation principles, applications, scale-up considerations, regulatory issues, and more. An essential guide for researchers in drug delivery, polymers, and biomaterials. Inhaltsverzeichnis List of Contributors xviiSeries Preface xxiPreface xxiii1 Self-Assembled Delivery Vehicles for Poorly Water-Soluble Drugs: Basic Theoretical Considerations and Modeling Concepts 1Sylvio May and Alfred Fahr1.1 Introduction 11.2 Brief Reminder of Equilibrium Thermodynamics 31.3 Principles of Self-Assembly in Dilute Solutions 71.4 Solubility and Partitioning of Drugs 111.5 Ways to Model Interactions in Colloidal Systems 161.6 Kinetics of Drug Transfer from Mobile Nanocarriers 231.7 Conclusion 292 Liposomes as Intravenous Solubilizers for Poorly Water-Soluble Drugs 37Peter van Hoogevest, Mathew Leigh and Alfred Fahr2.1 Introduction 372.2 Intravenous Administration of Poorly Water-Soluble Compounds (PWSC) 402.3 Conclusion 593 Drug Solubilization and Stabilization by Cyclodextrin Drug Carriers 67Thorsteinn Loftsson and Marcus E. Brewster3.1 Introduction 673.2 Structure and Physiochemical Properties 683.3 Cyclodextrin Complexes and Phase Solubility Diagrams 723.4 Cyclodextrin Complexes 763.5 Effects on Drug Stability 773.6 Cyclodextrins and Drug Permeation through Biological Membranes 803.7 Drug Solubilization in Pharmaceutical Formulations 823.8 Toxicology and Pharmacokinetics 893.9 Regulatory Issues 903.10 Conclusion 914 Solid Lipid Nanoparticles for Drug Delivery 103Sonja Joseph and Heike Bunjes4.1 Introduction 1034.2 Preparation Procedures for Solid Lipid Nanoparticles 1044.3 Structural Parameters and Their Influence on Product Quality and Pharmaceutical Performance 1164.4 Incorporation of Poorly Soluble Drugs and In Vitro Release 1234.5 Safety Aspects, Toxicity and Pharmacokinetic Profiles 1294.6 Conclusion 1335 Polymeric Drug Delivery Systems for Encapsulating Hydroph...

Autorentext
Dennis Douroumis
University of Greenwich, UK Alfred Fahr
Friedrich-Schiller University of Jena, Germany

Klappentext
Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, polymeric drug encapsulation delivery systems, self-microemulsifying drug delivery systems, nanocrystals, hydrosol colloidal dispersions, microemulsions, solid dispersions, cosolvent use, dendrimers, polymer- drug conjugates, polymeric micelles, and mesoporous silica nanoparticles. For each approach the book discusses the main instrumentation, operation principles and theoretical background, with a focus on critical formulation features and clinical studies. Finally, the book includes some recent and novel applications, scale-up considerations and regulatory issues. Drug Delivery Strategies for Poorly Water-Soluble Drugs is an essential multidisciplinary guide to this important area of drug formulation for researchers in industry and academia working in drug delivery, polymers and biomaterials.

Inhalt
List of Contributors xvii Series Preface xxi Preface xxiii 1 Self-Assembled Delivery Vehicles for Poorly Water-Soluble Drugs: Basic Theoretical Considerations and Modeling Concepts 1 Sylvio May and Alfred Fahr 1.1 Introduction 1 1.2 Brief Reminder of Equilibrium Thermodynamics 3 1.3 Principles of Self-Assembly in Dilute Solutions 7 1.4 Solubility and Partitioning of Drugs 11 1.5 Ways to Model Interactions in Colloidal Systems 16 1.6 Kinetics of Drug Transfer from Mobile Nanocarriers 23 1.7 Conclusion 29 2 Liposomes as Intravenous Solubilizers for Poorly Water-Soluble Drugs 37 Peter van Hoogevest, Mathew Leigh and Alfred Fahr 2.1 Introduction 37 2.2 Intravenous Administration of Poorly Water-Soluble Compounds (PWSC) 40 2.3 Conclusion 59 3 Drug Solubilization and Stabilization by Cyclodextrin Drug Carriers 67 Thorsteinn Loftsson and Marcus E. Brewster 3.1 Introduction 67 3.2 Structure and Physiochemical Properties 68 3.3 Cyclodextrin Complexes and Phase Solubility Diagrams 72 3.4 Cyclodextrin Complexes 76 3.5 Effects on Drug Stability 77 3.6 Cyclodextrins and Drug Permeation through Biological Membranes 80 3.7 Drug Solubilization in Pharmaceutical Formulations 82 3.8 Toxicology and Pharmacokinetics 89 3.9 Regulatory Issues 90 3.10 Conclusion 91 4 Solid Lipid Nanoparticles for Drug Delivery 103 Sonja Joseph and Heike Bunjes 4.1 Introduction 103 4.2 Preparation Procedures for Solid Lipid Nanoparticles 104 4.3 Structural Parameters and Their Influence on Product Quality and Pharmaceutical Performance 116 4.4 Incorporation of Poorly Soluble Drugs and In Vitro Release 123 4.5 Safety Aspects, Toxicity and Pharmacokinetic Profiles 129 4.6 Conclusion 133 5 Polymeric Drug Delivery Systems for Encapsulating Hydrophobic Drugs 151 Naveed Ahmed, C.E. Mora-Huertas, Chiraz Jaafar-Maalej, Hatem Fessi and Abdelhamid Elaissari 5.1 Introduction 151 5.2 Safety and Biocompatibility of Polymers 152 5.3 Encapsulation Techniques of Hydrophobic Drugs 156 5.4 Behavior of Nanoparticles as Drug Delivery Systems 173 5.5 Conclusion 177 6 Polymeric Drug Delivery Systems for Encapsulating Hydrophobic Drugs 199 Dagmar Fischer 6.1 Introduction 199 6.2 Drug Encapsulation by Monomer Polymerization 200 6.3 Polymeric Nanospheres and Nanocapsules Produced by Polymerization 209 6.4 Formulation Components 210 6.5 Control of Particle Morphology 212 6.6 Toxicity and In Vivo Performance 213 6.7 Scale-Up Considerations 214 6.8 Conclusion 217 7 Development of Self-Emulsifying Drug Delivery Systems (SEDDS) for Oral Bioavailability Enhancement of Poorly Solubl…

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