Cancer as a Metabolic Disease

Informationen zum Autor THOMAS N. SEYFRIED! PhD! has taught and conducted research in the fields of neurogenetics! neurochemistry! and cancer for more than twenty-five years at Yale University and Boston College. He has published more than 150 scientific articles and book chapters and is on the editorial boards of Nutrition & Metabolism! Journal of Lipid Research! Neurochemical Research! and ASN Neuro. Klappentext A groundbreaking new approach to understanding! preventing! and treating cancerSupported by evidence from more than 1!000 scientific and clinical studies! this groundbreaking book demonstrates that cancer is a metabolic disease and! more importantly! that it can be more effectively managed and prevented when it is recognized as such. Moreover! the book provides detailed evidence that the traditional view of cancer as a genetic disease has been largely responsible for the failure to develop effective therapies and preventive strategies.Cancer as a Metabolic Disease reevaluates the origins of cancer based on the latest research findings as well as several decades of studies exploring the defects in tumor cell energy metabolism. Author Thomas Seyfried is a biochemical geneticist who has been investigating the lipid biochemistry of cancer for thirty years. In this book! he carefully establishes why approaching cancer as a metabolic disease leads to better understanding and management of all aspects of the disease! including inflammation! vascularization! cell death! drug resistance! and genomic instability. In addition! the book explores:* Origin of metastasis* New treatment strategies that target tumor cell energy metabolism! including the ketogenic diet* More effective prevention strategies in light of the metabolic origin of cancer* Case studies and perspectives from the point of view of physicians! patients! and caregiversThroughout the book! tables! figures! and graphs summarize key information and clarify complex concepts. In addition! the renowned cancer biochemist Peter Pedersen from Johns Hopkins Medical School also provides a historical perspective on the importance of the information presented in his foreward to the book.Cancer as a Metabolic Disease is essential reading for all cancer researchers and clinicians as well as public health professionals. By treating cancer as a metabolic disease! the book sets readers on a new! more promising path to understanding the origins of cancer and developing new! more effective strategies to treat and prevent it. Zusammenfassung The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. Inhaltsverzeichnis 76608137 ...

Autorentext
THOMAS N. SEYFRIED, PhD, has taught and conducted research in the fields of neurogenetics, neurochemistry, and cancer for more than twenty-five years at Yale University and Boston College. He has published more than 150 scientific articles and book chapters and is on the editorial boards of Nutrition & Metabolism, Journal of Lipid Research, Neurochemical Research, and ASN Neuro.

Klappentext
A groundbreaking new approach to understanding, preventing, and treating cancer Supported by evidence from more than 1,000 scientific and clinical studies, this groundbreaking book demonstrates that cancer is a metabolic disease and, more importantly, that it can be more effectively managed and prevented when it is recognized as such. Moreover, the book provides detailed evidence that the traditional view of cancer as a genetic disease has been largely responsible for the failure to develop effective therapies and preventive strategies. Cancer as a Metabolic Disease reevaluates the origins of cancer based on the latest research findings as well as several decades of studies exploring the defects in tumor cell energy metabolism. Author Thomas Seyfried is a biochemical geneticist who has been investigating the lipid biochemistry of cancer for thirty years. In this book, he carefully establishes why approaching cancer as a metabolic disease leads to better understanding and management of all aspects of the disease, including inflammation, vascularization, cell death, drug resistance, and genomic instability. In addition, the book explores: * Origin of metastasis * New treatment strategies that target tumor cell energy metabolism, including the ketogenic diet * More effective prevention strategies in light of the metabolic origin of cancer * Case studies and perspectives from the point of view of physicians, patients, and caregivers Throughout the book, tables, figures, and graphs summarize key information and clarify complex concepts. In addition, the renowned cancer biochemist Peter Pedersen from Johns Hopkins Medical School also provides a historical perspective on the importance of the information presented in his foreward to the book. Cancer as a Metabolic Disease is essential reading for all cancer researchers and clinicians as well as public health professionals. By treating cancer as a metabolic disease, the book sets readers on a new, more promising path to understanding the origins of cancer and developing new, more effective strategies to treat and prevent it.

Zusammenfassung
The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited.

Inhalt
Forword xiii Preface xv 1. Images of Cancer 1 How Cancer is Viewed 2 References 13 2. Confusion Surrounds the Origin of Cancer 15 The Oncogenic Paradox 18 Hallmarks of Cancer 18 Reassessment 26 References 27 3. Cancer Models 31 Problems with Some Cancer Models 31 Animal Charges as a Major Impediment to Cancer Research 38 Problems with Tumor Histological Classification 39 Personal Perspective on Cancer 44 References 45 4. Energetics of Normal Cells and Cancer Cells 47 Metabolic Homeostasis 47 The Constancy of the G ATP 54 ATP Production in Normal Cells and Tumor Cells 55 Energy Production Through Glucose Fermentation 57 Glutaminolysis with or without Lactate Production 61 Transamination Reactions 64 TCA Cycle, Substrate-Level Phosphorylation 66 Cholesterol Synthesis and Hypoxia 67 Summary 67 References 68 5. Respiratory Dysfunction in Cancer Cells 73 Normal Mitochondria 74 Morphological Defects in Tumor Cell Mitochondria 77 Proteomic Abnormalities in Tumor Cell Mitochondria 79 Lipidomic Abnormalities in Tumor Cell Mitochondria 81 Cardiolipin: A Mitochondrial-Specific Lipid 83 Cardiolipin and Abnormal Energy Metabolism in Tumor Cells 85 Complicating Influence of the In Vitro Growth Environment on Cardiolipin Composition and Energy Metabolism 92 Mitochondrial Uncoupling and Cancer 97 Cancer Cell Heat Production and Uncoupled Mitochondria 98 Personal Perspective 99 Summary 100 References 101 6. The Warburg Dispute 107 Sidney Weinhouse's Criticisms of the Warburg Theory 108 Alan Aisenberg's Criticisms of the Warburg Theory 110 Sidney Colowick's Assessment of the Aisenberg Monograph 113 Apples and Oranges 114 References 116 7. Is Respiration Normal in Cancer Cells? 119 Pseudo-Respiration 119 How Strong is the Scientific Evidence Showing that Tumor Cells can Produce Energy Through OxPhos? 124 OxPhos Origin of ATP in Cancer Cells Reevaluated 124 What About OxPhos Expression in Other Tumors? 127 The Pedersen Review on Tumor Mitochondria and the Bioenergetics of Cancer Cells 128 References 129 8. Is Mitochondrial Glutamine Fermentation a Missing Link in the Metabolic Theory of Cancer? 133 Amino Acid Fermentation can Maintain Ce…

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