Molecular Toxicology

This book presents the biochemical and molecular biological fundamentals underlying toxicology and drug metabolism. It covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expressiong, and analysis of enzymes of biotransformation; and molecular toxicology of aromatic amines, nirosamines, polycyclic aromatic hydrocarbons, chlorinated compounds.

Klappentext
The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things atthe molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair, among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses, as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.

Zusammenfassung
Presents the biochemical and molecular biological fundamentals underlying toxicology and drug metabolism. This book covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expressing, and analysis of enzymes of biotransformation; and more.



Autorentext
P. David Josephy is Professor of Molecular and Cellular Biology at the University of Guelph. Bengt Mannervik is the Karin and Herbert Jacobsson Professor of Biochemistry at Uppsala University, Sweden.

Inhalt
Act One: Toxicity at the Cellular Level; 1. Toxicology of oxygen; 2. Covalent Binding of Xenobiotics to DNA and Protein; 3. DNA Repair; 4. Chemical Mutagenesis; 5. Oncogenes, tumor suppressor genes, and mutations in cancer cells; TUMORS; 6. Toxicity, survival, and target theory; Act Two: Enzymology of Biotransformation; 7. Cytochrome P450 - Chemical and Biochemical Aspects; 8. P450: Biological aspects; regulation; genetics; 9. Biochemistry of glutathione; 10. Glutathione transferases; 11. Glutathione and glutathione transferases: Toxicological and pharmacological aspects; 12. Glucuronidation; 13. Arylamine N-Acetyltransferase; 14. Sulfotransferase; Act Three: Molecular Principles Applied to Specific Toxicants; 15. Alkylating agents and "mustards"; 16. Oxidative stress in the erythrocyte: congenital and xenobiotic-induced methemoglobinemia; 17. Aromatic amines and related toxic compounds; 18. Polycyclic aromatic hydrocarbon carcinogens; 19. Acetaminophen

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