Asymmetric Synthesis with Chemical and Biological Methods

Asymmetric Synthesis with Chemical and Biological Methods

Einband:
Fester Einband
EAN:
9783527314737
Untertitel:
Englisch
Genre:
Chemie
Autor:
Dieter Enders, Karl-Erich Jaeger, Günter Helmchen
Herausgeber:
Wiley-VCH
Auflage:
1. Auflage
Anzahl Seiten:
446
ISBN:
978-3-527-31473-7

Presenting the latest developments, this book provides a deep, interdisciplinary insight into stoichiometric and catalytic reactions in this ever-expanding field, focusing on the synthesis of natural and bioactive compounds and both chemical and biological methods of catalysis.

Edited by two of the leading researchers in the field, this book provides a deep, interdisciplinary insight into stoichiometric and catalytic reactions in this continuously expanding area. A plethora of top German scientists with an international reputation covers various aspects, from classical organic chemistry to process development, and from the theoretical background to biological methods using enzymes. Throughout the focus is on the development of new synthetic methods in asymmetric synthesis, the synthesis of natural and bioactive compounds and the latest developments in both chemical and biological methods of catalysis, as well as the investigation of special technical and biotechnical aspects.

Autorentext
Dieter Enders completed his PhD at the Justus-Liebig-Universität Giessen under the supervision of D. Seebach. After postdoctoral studies at Harvard University with E. J. Corey, he returned to Giessen and completed his habilitation. He became Associate Professor at the Universität Bonn in 1980, and moved to his present position as Professor of Organic Chemistry at the RWTH Aachen in 1985. He has received many awards (Leibniz-Prize of the DFG, Emil Fischer Medal of the GDCh, Yamada Prize, Japan) for his research, which focuses on the asymmetric synthesis of biologically active compounds and the development of new synthetic methods. Karl-Erich Jaeger was born in Dortmund and studied biology and chemistry at the Ruhr-University Bochum, where he received his PhD under the supervision of U. Winkler. After postdoctoral studies with Robert E.W. Hancock at the Department of Microbiology of the University of British Columbia in Vancouver, he received his habilitation in Bochum in 1995. Karl-Erich Jaeger is currently Professor at the Heinrich-Heine University of Düsseldorf and Director of the Institute of Molecular Enzyme Technology at the Research Centre Jülich. His research interests include the expression, folding and secretion of bacterial enzymes, their optimization by directed evolution, and enantioselective biocatalysis.

Klappentext
Edited by two of the leading researchers in asymmetric synthesis, this book provides a deep, interdisciplinary insight in the ever-expanding field of stoichiometric and catalytic reactions. Presenting the latest developments, it focuses on the synthesis of natural and bioactive compounds and both chemical and biological methods of catalysis. Nineteen contributions from top research teams cover a plethora of various topics, ranging from classical organic chemistry to the development of new synthetic strategies, and from theory to reaction technology and enzyme use. All the important particulars of the individual techniques are investigated and delivered in highly readable fashion.

Inhalt
STOICHIOMETRIC ASYMMETRIC SYNTHESIS Development of Novel Enantioselective Synthetic Methods Asymmetric Synthesis of Natural Products Employing the SAMP/RAMP-Hydrazone Methodology Asymmetric Synthesis Based on Sulfonimidoyl-Substituted Allyltitanium Complexes The "Daniphos" Ligands: Synthesis and Catalytic Applications New Chiral Ligands Based on Substituted Heterometallocenes CATALYTIC ASYMMETRIC SYNTHESIS WITH CHEMICAL METHODS Sulfoximines as Ligands in Asymmetric Metal Catalysis Catalyzed Asymmetric Aryl Transfer Reactions Substituted [2.2]-Paracyclophane Derivatives as Efficient Ligands for Asymmetric 1,2- and 1,4-Addition Reactions Palladium-Catalyzed Allylic Alkylation of Sulfur and Oxygen Nucleophiles - Asymmetric Synthesis, Kinetic Resolution and Dynamic Kinetic Resolution The QUINAPHOS Ligand Family and its Application in Asymmetric Synthesis Immobilization of Transition Metal Complexes and their Application to Enantioselective Catalysis CATALYTIC ASYMMETRIC SYNTHESIS WITH BIOLOGICAL METHODS Directed Evolution to Increase the Substrate Range of Benzoylformate Decarboxylase from Pseudomonas Putida C-C Bonding Microbial Enzymes: Thiamine Diphosphate-Dependent Enzymes and Class I Aldolases Enzymes for Carboligation - 2-Ketoacid Decarboxylases and Hydroxynitrile Lyases Preparative Syntheses of Chiral Alcohols using (R)-specific Alcohol Dehydrogenases from Lactobacillus strains Biocatalytic C-C Bond Formation in Asymmetric Synthesis Exploring and Broadening the Biocatalytic Properties of Recombinant Sucrose Synthase 1 for the Synthesis of Sucrose Analogues Flexible Asymmetric Redox Reactions and C-C Bond Formation by Bioorganic Synthetic Strategies REACTION TECHNOLOGY IN ASYMMETRIC SYNTHESIS Reaction Engineering in Asymmetric Synthesis Biocatalyzed Asymmetric Syntheses Using Gel-Stabilized Aqueous-Organic Two-Phase Systems


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