Serotonin

This volume contains the Proceedings of the invited lectures of the Second International Sym posium on SEROTONIN from Cell Biology to Pharmacology and Therapeutics held in Houston, Texas September 15-18, 1992. The meeting was held under the co-sponsorship of the Serotonin Club, the Giovanni Lorenzini Medical Foundation, and the Fondazione Giovanni Lorenzini. This volume discusses the major exploration in knowledge that has occurred recently of the complex role that 5- hydroxytryptamine (serotonin) plays in health and disease. In par ticular, these Proceedings highlight major breakthroughs in molecular biology and classification of receptor subtypes that are responsible for the many actions of the monoamine. The ever increasing importance of serotonin in central regulation, whether autonomic or behavioral is represented by a large number of chapters prepared by world experts. Additionally, the role of serotonin in peripheral organs is also discussed. Hence, this volume provides the reader with a unique, up-to-date review of this exciting and novel area of science. These Proceedings obviously are of great interest, not only to the researchers directly engaged in the quest for the understanding and unraveling of the actions of the interactions with serotonin as a major neurohumoral mediator, but also to all scholars and clinicians who wish to acquire a better understanding of the functioning of the brain and of peripheral organs. Since this volume was constructed as a compilation of invited lectures, the scientific content and the opinions expressed in the chapters are the sole responsibility of the authors.

Inhalt
Preface.- 1. Different Organization of Human Monoamine Oxidase (MAO) A and B Promoters.- 2. Molecular Biology of Serotonin Uptake Sites.- 3. Molecular Biology of 5-HT1 Receptors.- 4. 5-HT-Receptor Agonists Block C-fos-LI within Trigeminal Nucleus Caudalis in Response to Noxious Meningeal Stimulation.- 5. A Reappraisal of 5-HT Receptor Classification.- 6. Classification of Agents Used in Serotonin Research.- 7. Electrophysiology of Central Serotonin Neurotransmission.- 8. Immunohistochemical Visualization of 5-HT1A Receptors in the Rat Brain.- 9. In Vitro Functional Correlates of 5-HT1-Like Receptors.- 10. 5-HT1D Receptor Subtypes.- 11. 5-HT3 Receptors.- 12. 5-HT4 Receptor: Current Status.- 13. Serotonergic Receptors: From Ligands to Sequence.- 14. Possible Mechanisms of Action of Drugs Effective Against Acute Migraine Attacks.- 15. SB 203186, A Potent 5-HT4 Antagonist for Cardiac 5-HT4 Receptors.- 16. Role of the Lateral Tegmental Field in the Sympatholytic Action of 5HT1A Agonists.- 17. Urapidil: The Role of 5-HT1A and Ó-Adrenergic Receptors in Blood Pressure Reduction.- 18. Clinical Aspects of Antiemesis: Role of the 5-HT3 Antagonists.- 19. The Antiemetic Properties of 5-HT3 Receptor Antagonists.- 20. Mechanisms of the Emetic Response to Chemotherapy and of the Antiemetic Action of 5-HT3 Receptor Antagonists: Clinical Studies.- 21. Serotonin and Serotonergic Drugs in Emesis.- 22. Clinical Effects of 5-HT3 Antagonists in Treating Nausea and Vomiting.- 23. Inhibitors of Serotonin Uptake.- 24. Preclinical Evidence for the Role of Serotonin Receptors in Anxiety.- 25. The Effects of Tryptophan Depletion in Depression.- 26. Anxiolytic Effects of Drugs Acting on 5-HT Receptor Subtypes.- 27. Obsessive Compulsive Disorders: A Neurobiological Hypothesis.- 28. Role of theSerotonergic System in Pituitary Hormone Secretion: The Pharmacologic Challenge Paradigm in Man.- 29. Serotonin in Anxiety and Related Disorders.- 30. Alcoholic Violent Offenders: Behavioral, Endocrine, Diurnal Rhythm, and Genetic Correlates of Low CSF 5-HIAA Concentrations.- 31. Modulation of Dopaminergic Neurotransmission by 5-HT2 Antagonism.- 32. Combined Serotonin 5-HT2 and Dopamine DA2 Antagonist Treatments in Chronic Schizophrenia.- 33. Is Serotonin Involved in the Pathogenesis of Schizophrenia.- 34. Serotonin Antagonists as Antipsychotics.- 35. Pharmacological Analysis of 5-HT Receptors in Human Small Coronary Arteries.- 36. Platelets, Platelet Mediators, and Unstable Coronary Artery Disease Syndromes.- 37. Abnormal Coronary Vasoconstrictor Responses to Serotonin in Patients with Ischemic Heart Disease.- 38. 5-HT and the Immune System.- 39. The Stimulatory Effects of d-Fenfluramine (d-FEN) on Blood and Splenic Immune Functions in the Fischer 344 Rat are Age and Sex Dependent.- 40. Serotonergic Regulation of Natural Killer Cells: A Minireview.- 41. Interactions between Serotonin and the Immune System: An Overview.- 42. The Role of Serotonin in the Cellular Physiological Effects of Cocaine.- 43. Serotonin Mechanisms in Ethanol Abuse.- 44. Serotonin Regulation of Alcohol Drinking.- 45. Hypothalamic Serotonin in Relation to Appetite for Macronutrients andEating Disorders.- 46. Serotonergic Pharmacology of Appetite.- 47. Serotonin (5-HT)IA Receptor Agonists and Neuroprotection.- 48. New Antidementia Molecules which Selectively Influence Serotonin Receptor Subtypes.- 49. Pharmacological Modulation of the Serotonergic System: An Overview of the Effects on Normal and Pathological Sleep.

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