Fundamental Bacterial Genetics

Zusatztext Auf der Grundlage der neuen Rentengesetzgebung Die Diskussionen um dieRenten werden immer schärfer und die Angst um ausreichende Altersversorgungwächst. Wer seinen gewohnten Lebensstandard auch später halten will! darfsich nicht mehr allein auf den Staat verlassen! sondern muß bereits frühzeitigselbst vorsorgen. Informationen zum Autor Janine E. Trempy , Ph.D., is an Associate Professor of Microbiology and the Associate Dean in the College of Science at Oregon State University. She has received numerous research and teaching awards from Oregon State University, and in 1996 she was named by the Carnegie Foundation/CASE as Oregon Professor of the Year for her development and use of innovative inquiry based cooperative learning environments. She was a Waksman/American Society for Microbiology Traveling Lecturer, presenting lectures focusing on science education reform. Her research focus is on bacterial crisis management systems, microbial applications (i.e. biosensor development; food safety) and developing inclusive learning environments that enhance science literacy. Nancy Trun is an Assistant Professor in the Dept of Biological Sciences at Duquesne University where she teaches undergraduate and graduate level microbial genetics. She has taught microbial genetics courses at the University of Maryland and at Cold Spring Harbor Laboratory and received the National Institutes of Health Director's Award for science education at the elementary school level. Currently, her research focus is on chromosome folding in bacteria. Klappentext Fundamental Bacterial Genetics presents a concise introduction to microbial genetics. The text focuses on one bacterial species, Escherichia coli , but draws examples from other microbial systems at appropriate points to support the fundamental concepts of molecular genetics. A solid balance of concepts, techniques, and applications makes this book an accessible, essential introduction to the theory and practice of fundamental microbial genetics. Fundamental Bacterial Genetics features: FYI boxes - feature key experiments that lead to what we now know, comparisons with other species and more. Study questions - at the end of each chapter, review and test students' knowledge of key chapter concepts. Key references - included both at chapter end and in a full reference list at the end of the book. Full chapter on bioinformatics and proteomics - includes coverage of functional genomics and microarrays. Dedicated website - www.blackwellpublishing.com/trun - animations, study resources, web research questions, and illustrations downloadable for PowerPoint files provide students and instructors with an enhanced, interactive experience. Zusammenfassung Presents an introduction to microbial genetics. This book focuses on one bacterial species! Escherichia coli! but draws examples from other microbial systems at appropriate points to support the fundamental concepts of molecular genetics. ...

Autorentext
Janine E. Trempy, Ph.D., is an Associate Professor of Microbiology and the Associate Dean in the College of Science at Oregon State University. She has received numerous research and teaching awards from Oregon State University, and in 1996 she was named by the Carnegie Foundation/CASE as Oregon Professor of the Year for her development and use of innovative inquiry based cooperative learning environments. She was a Waksman/American Society for Microbiology Traveling Lecturer, presenting lectures focusing on science education reform. Her research focus is on bacterial crisis management systems, microbial applications (i.e. biosensor development; food safety) and developing inclusive learning environments that enhance science literacy. Nancy Trun is an Assistant Professor in the Dept of Biological Sciences at Duquesne University where she teaches undergraduate and graduate level microbial genetics. She has taught microbial genetics courses at the University of Maryland and at Cold Spring Harbor Laboratory and received the National Institutes of Health Director's Award for science education at the elementary school level. Currently, her research focus is on chromosome folding in bacteria.

Klappentext
Fundamental Bacterial Genetics presents a concise introduction to microbial genetics. The text focuses on one bacterial species, Escherichia coli, but draws examples from other microbial systems at appropriate points to support the fundamental concepts of molecular genetics. A solid balance of concepts, techniques, and applications makes this book an accessible, essential introduction to the theory and practice of fundamental microbial genetics. Fundamental Bacterial Genetics features: FYI boxes - feature key experiments that lead to what we now know, comparisons with other species and more. Study questions - at the end of each chapter, review and test students' knowledge of key chapter concepts. Key references - included both at chapter end and in a full reference list at the end of the book. Full chapter on bioinformatics and proteomics - includes coverage of functional genomics and microarrays. Dedicated website - www.blackwellpublishing.com/trun - animations, study resources, web research questions, and illustrations downloadable for PowerPoint files provide students and instructors with an enhanced, interactive experience.

Zusammenfassung
Presents an introduction to microbial genetics. This book focuses on one bacterial species, Escherichia coli, but draws examples from other microbial systems at appropriate points to support the fundamental concepts of molecular genetics.

Inhalt
1. Introduction To The Cell.The Molecules That Make Up A Cell.The Bacterial Cell: A Quick Overview.How Do Cells Grow?.What Is Genetics?.Summary.2. The Bacterial Dna Molecule.The Structure Of DNA And RNA.Deoxyribonucleosides And Deoxyribonucleotides.DNA Is Only Polymerized 5' To 3'.Double-Stranded Dna.Supercoiling Double-Stranded Dna.Replication Of The Escherichia Coli Chromosome.Constraints That Influence Dna Replication.The Replication Machinery.Dna Polymerases.Dnag Primase.Replication Of Both Strands.Theta Mode Replication.Minimizing Mistakes In Dna Replication.The Dna Replication Machinery As Molecular Tools.Summary.3. Mutations.Phenotype And Genotype.Classes Of Mutations.Point Mutations And Their Consequences.Measuring Mutations: Rate And Frequency.Spontaneous And Induced Mutations.Errors During Dna Replication: Incorporation Errors.Errors Due To Tautomerism.Spontaneous Alteration By Depurination.Spontaneous Alteration By Deamination.Alterations By Spontaneous Genetic Rearrangement.Alterations Caused By Transposition.Induced Mutations.Chemicals That Mimic Normal Dna Bases: Base Analogues.Chemicals That React With Dna Bases: Base Modifiers.Chemicals That Bind Dna Bases: Intercalators.Mutagens That Physically Damage The Dna: Ultraviolet Light And Ionizing.Radiation.Mutator Strains.Reverting Mutations.Suppression.Ames Test.How Have We Exploited Bacterial Mutants.Summary.4. Dna Repair.Lesions That Constitute Dna Damage.Reverse, Excise Or Tolerate?.Mechanisms That Reverse Dna Damage.Photoreactivation.O6-Methylguanine Or O4-Methylthymine Methyltransferase.Mechanisms That Excise Dna Damage.Uvrabc Directed Nucleotide Excision Repair.Muthls Methyl Directed Mismatch Repair.Very Short Patch Repair.Glycosylases.Uracil-N-Glycosylase Coupled With Ap Excision Repair.Deaminated Bases Removed By Dna Glycosylase.Alkylated Bases Removed By Dna Glycosylase.Mutm/Muty: Oxidative Damage.N-Glycosylases Specific For Pyrimidine Dimmers.Mechanisms That Tolerate Dna Damage.Transdimer Synthesis.Post Replication/Recombinational Repair (Prr).Introduction To The Sos Regulon.Summary.5. Recombination:.Homologous Recombination.Models For Homologous Recombinatio…

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