Microbial Proteomics

Informationen zum Autor IAN HUMPHERY-SMITH! PHD! is the Founding Chair of the Department of Pharmaceutical Proteomics at Utrecht University. Dr. Humphery-Smith has served as director of the Centre for Proteome Research and Gene-Product Mapping and served as managing director and chief scientific officer of Glaucus Proteomics BV.MICHAEL HECKER! PHD! is Professor of Microbiology and Head of the Institute for Microbiology at Ernst-Moritz-Arndt-University of Greifswald in Germany. Dr. Hecker is currently Vice Chair of the International Union of Microbiological Societies (IUMS). Klappentext Discover important lessons learned about whole organism biology via microbial proteomicsThis text provides an exhaustive analysis and presentation of current research in the field of microbial proteomics, with an emphasis on new developments and applications and future directions in research. The editors and authors show how and why the relative simplicity of microbes has made them attractive targets for extensive experimental manipulation in a quest for both improved disease prevention and treatment and an improved understanding of whole organism functional biology. In particular, the text demonstrates how microbial proteomic analyses can aid in drug discovery, including identification of new targets, novel diagnostic markers, and lead optimization.Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent and thorough approach throughout. Methods, technologies, and tools associated with the most promising approaches are stressed. Key topics covered include:* Microbial pathogenesis at the proteome level* Whole cell modeling* Structural proteomics and computational analysis* Biomolecular interactions* Physiological proteomics* Metabolic reconstruction using proteomics dataWhile presenting the practical utility of proteomics data, the text is also clear on the field's current limitations, pointing to areas where further investigation is needed.Offering a state-of-the-art perspective from internationally recognized experts, this text is ideally suited for researchers and students across the gamut of genomic sciences, including biochemistry, microbiology, molecular biology, genetics, biomedical and pharmaceutical sciences, biotechnology, and veterinary science. Zusammenfassung Discover important lessons learned about whole organism biology via microbial proteomicsThis text provides an exhaustive analysis and presentation of current research in the field of microbial proteomics, with an emphasis on new developments and applications and future directions in research. The editors and authors show how and why the relative simplicity of microbes has made them attractive targets for extensive experimental manipulation in a quest for both improved disease prevention and treatment and an improved understanding of whole organism functional biology. In particular, the text demonstrates how microbial proteomic analyses can aid in drug discovery, including identification of new targets, novel diagnostic markers, and lead optimization.Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent and thorough approach throughout. Methods, technologies, and tools associated with the most promising approaches are stressed. Key topics covered include:* Microbial pathogenesis at the proteome level* Whole cell modeling* Structural proteomics and computational analysis* Biomolecular interactions* Physiological proteomics* Metabolic reconstruction using proteomics dataWhile presenting the practical utility of proteomics data, the text is also clear on the field's current limitations, pointing to areas where further investigation is needed.Offering a state-of-the-art perspective from internationally recognized experts, this text is ideally suited for researchers and students across the gamut of gen...

Autorentext
IAN HUMPHERY-SMITH, PHD, is the Founding Chair of the Department of Pharmaceutical Proteomics at Utrecht University. Dr. Humphery-Smith has served as director of the Centre for Proteome Research and Gene-Product Mapping and served as managing director and chief scientific officer of Glaucus Proteomics BV. MICHAEL HECKER, PHD, is Professor of Microbiology and Head of the Institute for Microbiology at Ernst-Moritz-Arndt-University of Greifswald in Germany. Dr. Hecker is currently Vice Chair of the International Union of Microbiological Societies (IUMS).

Klappentext
Discover important lessons learned about whole organism biology via microbial proteomics This text provides an exhaustive analysis and presentation of current research in the field of microbial proteomics, with an emphasis on new developments and applications and future directions in research. The editors and authors show how and why the relative simplicity of microbes has made them attractive targets for extensive experimental manipulation in a quest for both improved disease prevention and treatment and an improved understanding of whole organism functional biology. In particular, the text demonstrates how microbial proteomic analyses can aid in drug discovery, including identification of new targets, novel diagnostic markers, and lead optimization. Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent and thorough approach throughout. Methods, technologies, and tools associated with the most promising approaches are stressed. Key topics covered include: * Microbial pathogenesis at the proteome level * Whole cell modeling * Structural proteomics and computational analysis * Biomolecular interactions * Physiological proteomics * Metabolic reconstruction using proteomics data While presenting the practical utility of proteomics data, the text is also clear on the field's current limitations, pointing to areas where further investigation is needed. Offering a state-of-the-art perspective from internationally recognized experts, this text is ideally suited for researchers and students across the gamut of genomic sciences, including biochemistry, microbiology, molecular biology, genetics, biomedical and pharmaceutical sciences, biotechnology, and veterinary science.

Inhalt
PREFACE. ACKNOWLEDGMENTS. CONTRIBUTORS. PART I: GENERAL PROTEOMICS OF MICROORGANISMS/MODEL ORGANISMS. 1. Holistic Biology of Microorganisms: Genomics, Transcriptomics, and Proteomics (Valerie Wasinger). 2. Strategies for Measuring Dynamics: The Temporal Component of Proteomics (Robert J. Beynon and Julie M. Pratt). 3. Quest for Complete Proteome Coverage (C. David O'Connor, Ian N. Clarke, and Paul Skipp). 4. Proteome of Mycoplasma pneumoniae (Richard Herrmann and Thomas Ruppert). 5. Proteomics of Archaea (Ricardo Cavicchioli, Amber Goodchild, and Mark Raftery). PART II: PROTEOMICS AND CELL PHYSIOLOGY. 6. Elucidation of Mechanisms of Acid Stress in Listeria monocytogenes by Proteomic Analysis (Luu Phan-Thanh and Lothar Jänsch). 7. Oxidation of Bacterial Proteome in Response to Starvation (Thomas Nyström). 8. Tale of Two Metal Reducers: Comparative Proteome Analysis of Geobacter sulferreducens PCA and Shewanella oneidensis MR-1 (Carol S. Giometti). 9. AMT Tag Approach to Proteomic Characterization of Deinococcus radiodurans and Shewanella oneidensis (Mary S. Lipton, Margaret F. Romine, Matthew E. Monroe, Dwayne A. Elias, Ljiljana Pasa-Tolic, Gordon A. Anderson, David J. Anderson, Jim Fredrickson, Kim K. Hixson, Christophe Masselon, Heather Mottaz, Nikola Tolic, and Richard D. Smith). PART III: PHYSIOLOGICAL PROTEOMICS OF INDUSTRIAL BACTERIA. 10. Proteomics of Corynebacterium glutamicum: Essential Industrial Bacterium (Andreas Burkovski). 11. Proteomics of Lactococcus lactis: Phenotypes for a Domestic Bacterium (Mogens Kilstrup). 12. Proteomic Survey through Secretome of Bacillus subtilis (Haike Antelmann, Jan Maarten van Dijl, Sier…

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