Polycystic Kidney Disease

Autosomal dominant polycystic kidney disease is thought to be the commonest disorder inherited autosomally. This book provides a review of the genetics, pathophysiology, evaluation, and management of autosomal diseases, and is of interest to both basic researchers and clinicians in nephrology.

This is a further addition to the 'Oxford Clinical Nephrology' Series and provides an extensive review of our current knowledge on polycystic kidney disease...Overall this is an excellent book and provides much useful information for both the diagnosis and management of renal cystic diseases. It can be highly recommended, not just for the outstanding way the subject has been approached, but because the book also contains useful background information which greatly enhances the overall value.

Klappentext
Many inherited diseases and non-herediatry disorders have in common the development of renal cyctic disease. The most common, autosonal dominant polycystic kidney disease, is responsible for 5-10% of end-stage renal failure treated by dialysis or transplantation.
Since the publication six years ago of the last book on polycystic kidney disease, a number of genes causing the disease have been identified, mapped, or sequenced; new experimental models and the application of molecular biology techniques have provided new insights into the pathogenesis of polycystic kidney disease; novel clinical studies have provided valuable information for the prevention, evaluation, and treatment of the complications of this disease. This book provides an updated, state-of-the-art review of the genetics, pathophysiology, evaluation, and management of these diseases and will be of interest to both basic researchers and clinicians in nephrology.

Zusammenfassung
Many inherited diseases and non-hereditary disorders have in common the development of renal cystic disease. The most common, autosonal dominant polycystic kidney disease, is responsible for 5-10% of end-stage renal failure treated by dialysis or transplantation. Since the publication six years ago of the last book on polycystic kidney disease, a number of genes causing the disease have been identified, mapped, or sequenced; new experimental models and the application of molecular biology techniques have provided new insights into the pathogenesis R polycystic kidney disease; novel clinical studies have provided valuable information for the prevention, evaluation, and treatment of the complications of this disease. This book provides an updated, state-of-the-art review of the genetics, pathophysiology, evaluation, and management of these diseases and will be of interest to both basic researchers and clinicians in nephrology.

Inhalt
Part I: Cystic renal disease: experimental models and pathology; 1. Principles of molecular biology as applied to the study of disease; 2. In vitro models in the study of renal cystogenesis; 3. Mouse models of polycystic kidney disease; 4. In vivo models in non-murine species; 5. Pathogenesis of polycystic kidney disease: basement membrane and extracellular matric; 6. Pathogenesis of polycystic kidney disease: altered cellular function; Part II: Cystic renal disease: clinical spectrum; 7. Classification of cystic kidneys; 8. Diagnostic imaging of renal cystic diseases; 9. Autosomal recessive polycystic kidney disease: clinical and genetic profiles; 10. Acquired renal cystic disease; 11. Tuberous sclerosis; COMPLEX; 12. Von Hippel-Lindau Disease; Part III: Adult polycystic kidney disease: natural history and genetics; 13. Definition and natural history of autosomal dominant polycystic kidney disease; 14. Cloning strategies and genetics of type 1 autosomal dominant polycystic kidney disease; Part IV: Adult polycystic kidney disease: clinical features; 16. Hypertension in polycystic kidney disease; 17. Progression to renal insufficiency; 18. Management of end-stage renal failure and problems of transplantation in autosomal dominant polycystic kidney disease; 19. Chronic pain and its medical and surgical management in renal cystic disease; Part V: Adult polycystic kidney disease: complications; 20. Miscellaneous renal and systemic complications of autosomal dominant polycystic kidney disease including infection; 21. Polycystic liver disease; 22. Intracranial aneurysms in autosomal dominant polycystic kidney disease; 23. Particular problems in childhood and adolescents in autosomal dominant polycystic kidney disease; 24. Counselling and ethical considerations in autosomal polycystic kidney disease

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