Animal Models in Diabetes Research

Detailing the latest protocols for researching animal models of diabetes, especially resistant groups of rodents such as the NOD mouse, and including expert advice on implementation, this is a valuable new volume in the Methods in Molecular Biology series.

In recent years, human studies have made enormous contributions towards an understanding of the genetic basis of diabetes mellitus; however, most of the experimentation needed for the invention and testing of novel therapeutic approaches cannot be performed in humans. Thus, there is no alternative to appropriate animal models. In Animal Models in Diabetes Research, expert researchers explore the current status of the most important models and procedures in order to provide a timely resource in experimental diabetology. The first half of the volume serves as a comprehensive overview on our current knowledge of the pathogenesis and pathophysiology of diabetes in animal models through a series of reviews in model strains. The book then continues with vital, established protocols that are employed in the characterization and study of animal models of diabetes. As a volume in the highly successful Methods in Molecular Biology™ series, this work contains the type of detailed description and key implementation advice necessary to achieve successful results. Authoritative and cutting-edge, Animal Models in Diabetes Research delivers essential content that will be an important resource to advance diabetes research in the years to come.

Emphasizes rodent strains that develop autoimmunity such as the NOD mouse, the Akita mouse, and the BB rat Features practical, cutting-edge protocols that are ready for the lab Includes expert tips and key implementation advice to ensure successful results Includes supplementary material: sn.pub/extras Includes supplementary material: sn.pub/extras

Inhalt
The Non-Obese Diabetic (NOD) Mouse as a Model of Human Type 1 Diabetes.- Assessment of Diabetic Nephropathy in the Akita Mouse.- The BB Rat as a Model of Human Type 1 Diabetes.- Diabetes in Mice with Monogenic Obesity: The db/db Mouse and Its Use in the Study of Cardiac Consequences.- Pathophysiology and Genetics of Obesity and Diabetes in the New Zealand Obese Mouse: A Model of the Human Metabolic Syndrome.- The TALLYHO Mouse as a Model of Human Type 2 Diabetes.- Diet-Induced Diabetes in the Sand Rat (Psammomys obesus).- Diabetes in Zucker Diabetic Fatty Rat.- The GK Rat: A Prototype for the Study of Non-Overweight Type 2 Diabetes?.- Experimentally Induced Rodent Models of Type 2 Diabetes.- Investigation and Treatment of Type 2 Diabetes in Nonhuman Primates.- Determination of Beta-Cell Function: Insulin Secretion of Isolated Islets.- Determination of Beta-Cell Function: Ion Channel Function in Beta Cells.- Measurement of Glucose Homeostasis In Vivo: Glucose and Insulin Tolerance Tests.- Measurement of Glucose Homeostasis In Vivo: Combination of Tracers and Clamp Techniques.- Measurement of Insulin Sensitivity in Skeletal Muscle In Vitro.- Beta-Cell Autoimmunity.- Positional Cloning of Diabetes Genes.- Retinal Digest Preparation: A Method to Study Diabetic Retinopathy.- Lineage Tracing of Pancreatic Stem Cells and Beta Cell Regeneration.- Genetic Lineage Tracing of Beta Cell Neogenesis.

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