Handbook of Venoms and Toxins of Reptiles

Autorentext
Stephen P. Mackessy is Professor of Biology in the School of Biological Sciences at the University of Northern Colorado (UNC). His research broadly encompasses the biology of venomous snakes and the biochemistry of snake venoms, and he has published over one hundred scientific papers, book chapters, and natural history notes.

Klappentext
A decade after publication of the first edition, Handbook of Venoms and Toxins of Reptiles responds to extensive changes in the field of toxinology to endure as the most comprehensive review of reptile venoms on the market. The six sections of this new edition, which has nearly doubled in size, complement the original handbook by presenting current information from many of the leading researchers and physicians in toxinology, with topics ranging from functional morphology, evolution and ecology to crystallography, -omics technologies, drug discovery and more. With the recent recognition by the World Health Organization of snakebite as a neglected tropical disease, the section on snakebite has been expanded and includes several chapters dealing with the problem broadly and with new technologies and the promises these new approaches may hold to counter the deleterious effects of envenomation. This greatly expanded handbook offers a unique resource for biologists, biochemists, toxicologists, physicians, clinicians, and epidemiologists, as well as informed laypersons interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation.

Zusammenfassung
The most comprehensive review of reptile venoms on the market, this completely updated and greatly expanded handbook offers a "one-stop shop" to all those interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation.

Inhalt
PrefaceAbout the EditorContributorsSection I: Introduction and Technologies Used in Toxinology1. Reptile venoms and toxins: Unlimited opportunities for basic and applied research Stephen P. Mackessy2. Present and future of snake venom proteomics profiling Juan J. Calvete and Bruno Lomonte3. Applications of genomics and related technologies for studying reptile venoms Drew R. Schield, Blair W. Perry, Giulia I.M. Pasquesi, Richard W. Orton, Zachary L. Nikolakis, Aundrea K. Westfall, Todd A. Castoe4. Snake venom gland transcriptomics Cassandra M. Modahl and Rajeev Kungur Brahma5. X-ray crystallography and structural studies of toxins Vinícius Lucatelle da Silva, Ricardo Barros Mariutti, Mônika Aparecida Coronado, Raphael Josef Eberle, Fábio Rogério de Moraes and Raghuvir Krishnaswamy Arni6. Envenomations and Treatment: Translating between the bench and the bedside Nicklaus Brandehoff and Jordan Benjamin7. Current assessment of the state of snake venom toxinological research with a view to the future Sarah Natalie Cirilo Gimenes and Jay W. FoxSection II: Venom Gland Structure, Systematics and Ecology8. Reptile venom glands: Form, function, future, concepts and controversies Scott A. Weinstein9. Advances in venomous snake systematics, 2009-2019 - Wolfgang Wüster10. Biochemical ecology of venomous snakes Cara F. Smith and Stephen P. Mackessy11. Resistance of native species to reptile venoms Danielle H. DrabeckSection III: Reptile Venom Non-enzymatic Toxins12. Three-finger toxins Rajeev Kungur Brahma, Cassandra M. Modahl andR. Manjunatha Kini 13. Myotoxin a, crotamine and defensin homologs in reptile venoms Lucas C. Porta, Pedro Z. Amaral, Paulo Z. Amaral and Mirian A. F. Hayashi14. Reptile venom disintegrins Anthony J. Saviola and Juan J. Calvete15. Reptile venom cysteine-rich secretory proteins María Elisa Peichoto and Marcelo Larami Santoro16. Bradykinin-potentiating and related peptides from reptile venoms - Daniel Carvalho Pimenta and Patrick Jack Spencer 17. Exendins and its related proteins Michelle Khai Khun Yap and Nurhamimah Misuan18. Reptile venom C-type-lectins Kenneth J. Clemetson19. Snake venom Kunitz-type inhibitors and cystatins structure and function Elda E. Sánchez, Emelyn Salazar, Montamas Suntravat and Francisco Torres20. Small molecular constituents of snake venoms Alejandro Villar-Briones and Steven D. Aird21. Cobra venom factor: Structure, function, biology, research tool and drug lead Carl-Wilhelm Vogel, Brian E. Hew and David C. Fritzinger22. Snake toxins targeting diverse ion channels - Matan Geron and Avi PrielSection IV: Reptile Venom Enzyme Toxins23. Thrombin-like serine proteinases in reptile venoms Stephen D. Swenson, Samantha Stackand Francis S. Markland Jr.24. Snake venom metalloproteinases Charlotte A. Dawson, Stuart Ainsworth, Laura-Oana Albulescu and Nicholas R. Casewell25. Snake venom matrix metalloproteinases (svMMPs): Alternative proteolytic enzymes in rear-fanged snake venoms Inácio L. M. Junqueira-de-Azevedo and Juan David Bayona-Serrano26. Snake venom phospholipase A2 toxins Bruno Lomonte and Igor Kriaj27. Reptile venom L-amino acid oxidases structure and function Juliana P. Zuliania, Mauro V. Paloschi, Adriana S. Pontes, Charles N. Boeno, Jéssica A. Lopes, Sulamita S. Setubal, Fernando B. Zanchi and Andreimar M. Soares28. Snake venom nucleases, nucleotidases, and phosphomonoesterases - Jüri Siigur and Ene Siigur29. Reptile venom acetylcholinesterases - Mushtaq Ahmed, Wasim Ahmad, Nadia Mushtaq,Rehmat Ali Khan and Maria Rosa Chitolina Schetinger30. Inhibitors of reptile venom toxins Ana F. Gómez Garay, Jorge J. Alfonso, Anderson M. Kayano, Juliana C. Sobrinho, Cleopatra A. S. Caldeira, Rafaela Diniz-Sousa, Fernando B. Zanchi, Juliana P. Zuliani, and Andreimar M. SoaresSection V: Global Approaches to Envenomations and Treatments31. Snakebite envenomation as a neglected tropical disease: new impetus for confronting an old scourge José María Gutiérrez32. Current industrial production of snake antivenoms Mariángela Vargas, Melvin Sánchez, Andrés Hernández, Aarón Gómez, Mauricio Arguedas, Andrés Sánchez, Laura Sánchez, Mauren Villalta, María Herrera and Álvaro Segura33. Antivenom in the age of recombinant DNA technology Andreas H. Laustsen34. Epidemiology and treatment of reptile envenomations in the United States Daniel E. Keyler and Nicklaus Brandehoff35. Envenomations by reptiles in México Edgar Neri-Castro, Melisa Bénard-Valle, Jorge López de León, Leslie Boyer and Alejandro Alagón36. Snakebite envenomation in Central America: Epidemiology, pathophysiology and treatment José María Gutiérrez37. Snakebite in Southeast Asia: Envenomation and clinical management Nget Hong Tan, Kae Yi Tan and Choo Hock Tan38. Snake envenomation: Therapy and challenges in India Ashis K. Mukherjee, Bhargab Kalita, Sumita Dutta, Aparup Patra, Chitta R. Maiti and Dileep Punde39. Snakebite in Africa: Current situation and urgent needs Jean-Philippe Chippaux40. Approaches to snake envenomation in Southern Africa - James Pattinson, George Oosthuizen, Colin R. Tilbury and Darryl WoodSection VI: Reptile Venoms Production and as a Source of Therapeutics41. Large-scale snake colonies for venom production: Considerations and challenges Kristen L. Wiley and James R. Harrison42. Toxins to drugs biochemistry and pharmacology Zoltan Takacs

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