Cancer Genomics

Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment.

Klappentext
The rapidly evolving field of cancer genomics is driven by new, emerging technologies that have led to the realization that an individual's cancer is unique and likely most effectively treated by personalized therapies that address the genetic characteristics of a given tumor and a patient's pharmacogenomic profile. The technologies driving cancer genomics can be broadly divided into approaches that determine genetic, epigenetic (e.g. DNA methylation, histone modification), transcriptional, or protein expression changes between normal and cancerous tissue. Cancer genomics as a field has now made it possible to pinpoint differences not only between tumors among individuals but between cancer cells within the same individual over time and during the course of the cancer treatment.

This book addresses how recent technological advances are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. The "Future Directions" section highlights emerging model systems and techniques as well as the impact of rapidly changing technology on clinical trials. Important aspects of cancer genomics, including its role in altering how we as a society look at personal privacy in the context of medical treatment, economic disparities in cancer diagnosis, and treatment based on access to typically costly cutting-edge genomics, are also addressed. Ethical issues are discussed as they relate to cancer biology and genomics.


Zusammenfassung
".provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies." --Anticancer Research 34, 2014

Inhalt
Introduction1. Historical Overview Methodological Approaches and Background2. Expression Arrays (SNPs, etc.)3. Tissue micro-arrays (breast, ovarian) 4. Next generation sequencing (DNAseq) 5. RNAseq (breast cancer, sarcomas)6. Epigenetic Analyses7. Pharmcogenomics8. Biomarker discovery through genomics 9. Preclinical models for genomics (cell culture, transgenic animals, xenografts) 10. Bioinformatics and computational methods for data analysis11. Genomic Resource Projects - The Cancer Genome Atlas (TCGA) International Cancer Genome Consortium (ICGC) Ethics of Genomics Research 12. Ethics of Genomics Research The Genomics, Epigenomics and Transcriptomics of Cancer13. Somatic mutations, Transcription and Epigenetics Overview Adult Solid Tumors14. Lung Cancer15. Breast Cancer16. Prostate Cancer17. Colon Cancer18. Thyroid Cancer Age Non-specific Tumors and Hematopoietic Malignancies19. ALL 20. AML21. NHL22. Multiple Myeloma23. Brain Tumors Pediatric Cancers24. Neuroblastoma25. Soft tissue sarcomas26. Osteosarcoma27. Wilms Tumors Germline Mutations and Hereditary Cancer Syndromes 28. Germline Mutations and Hereditary Cancer Syndromes Future Directions29. The role of microRNAs and ultraconserved non-coding RNAs in cancer30. Environmental impact on cancer genomics

#	Onlineshop	Preis CHF	Versand CHF	Total CHF
1	Seller	0.00	0.00	0.00